Allosteric regulation in drug design

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Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of one drug alters the activity of the second. We found two unrelated drugs, RAPT...

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ژورنال

عنوان ژورنال: Current Trends in Biomedical Engineering & Biosciences

سال: 2017

ISSN: 2572-1151

DOI: 10.19080/ctbeb.2017.04.555630